Isospec Analytics and Danone Research collaborate on the identification of novel HMO's

We are excited to announce a new joint publication between Isospec Analytics SA and Danone Research, entitled “Characterization of rare trifucosylated human milk oligosaccharides by cryogenic infrared ion spectroscopy (CIRIS).”

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Human milk oligosaccharides (HMOs) are complex sugars that play a vital role in infant nutrition and immune development. However, the structural details of  many HMOs remain unresolved due to the analytical challenges of distinguishing closely related isomers.

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In this study, we applied cryogenic infrared ion spectroscopy (CIRIS) in combination with advanced mass spectrometry to precisely characterize four novel trifucosylated HMOs for which no analytical standards exist, including structures not previously explained by known biosynthetic pathways. This work expands our understanding of the diversity and biological complexity of HMOs and provides a powerful analytical framework for future discoveries in glycobiology and nutrition science.

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This collaboration highlights the value of bridging cutting-edge analytical innovation with applied nutritional research—paving the way for new insights into early-life development and potential innovations in infant nutrition.

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https://rdcu.be/eIphf

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Authors: Ali H. Abikhodr, Stephan Warnke, Ahmed Ben Faleh, Thomas R. Rizzo (Isospec Analytics / EPFL), Sibel Goeraler, John Gonsalves, Bernd Stahl, Marko Mank (Danone Research & Utrecht University).

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